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Rabbit Anti-Neurochondrin/AP Conjugated antibody (bs-19517R-AP)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-19517R-AP
英文名稱 Rabbit Anti-Neurochondrin/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的神經軟骨蛋白NCDN1抗體
別    名 AU042419; KIAA0607; M-Sema F-associating protein of 75 kDa; MGC93259; MMS10-AE; Ms10ae; NCDN; NCDN-1; Neurochondrin 1; Norbin; OTTHUMP00000065369; OTTHUMP00000065370; OTTHUMP00000065371; Sfap75.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  神經生物學  信號轉導  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, )
產品應用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 79kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Neurochondrin
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2008]

Function:
Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling By similarity. Required for the spatial learning process. Acts as a negative regulator of Ca2+-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth.

Subcellular Location:
Cytoplasm. Cell projection, dendrite.

Tissue Specificity:
Abundantly expressed in whole adult brain and in all individual brain regions examined, including spinal cord. Weakly expressed in ovary, testis, fetal brain and small intestine.

Similarity:
Interacts with SEMA4C, DIAPH1 (via FH3 domain) and GRM5 By similarity. Interacts with MCHR1.

Database links:

Entrez Gene: 23154 Human

Entrez Gene: 505994 Cow

Entrez Gene: 26562 Mouse

Entrez Gene: 89791 Rat

Omim: 608458 Human

SwissProt: Q2KJ97 Cow

SwissProt: Q9UBB6 Human

SwissProt: Q91YH7 Mouse

SwissProt: O35095 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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