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Rabbit Anti-Triosephosphate isomerase/BF488 Conjugated antibody (bs-4042R-BF488)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-4042R-BF488
英文名稱 Rabbit Anti-Triosephosphate isomerase/BF488 Conjugated antibody
中文名稱 BF488標記的磷酸丙糖異構酶抗體
別    名 TIM; TPI 1; TPI; TPI1; Triose phosphate isomerase 1; Triose phosphate isomerase; Triosephosphate isomerase 1; Triosephosphate isomerase; MGC88108; TPIS_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  神經生物學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 27kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Triosephosphate isomerase
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

Subunit:
Homodimer.

Post-translational modifications:
The initiator methionine for isoform 2 is removed.

DISEASE:
Triosephosphate isomerase deficiency (TPI deficiency) [MIM:190450]: Autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the triosephosphate isomerase family.

Database links:

UniProtKB/Swiss-Prot: P60174.3

Entrez Gene: 281543 Cow

Entrez Gene: 7167 Human

Entrez Gene: 21991 Mouse

Entrez Gene: 24849 Rat

Omim: 190450 Human

SwissProt: Q5E956 Cow

SwissProt: P54714 Dog

SwissProt: P60174 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

????磷酸丙糖異構酶(Triose-phosphate isomerase,通常簡稱為TPI或TIM)是一種能夠催化丙糖磷酸異構體在二羥丙酮磷酸和D型甘油醛-3-磷酸之間轉換。
????磷酸丙糖異構酶在糖酵解中具有重要作用,對于有效的能量生成是必不可少的。磷酸丙糖異構酶被發現存在于幾乎所有的生物體,包括哺乳動物、昆蟲、真菌、植物和大多數細菌中。
????如果人體缺乏磷酸丙糖異構酶,會導致嚴重的神經系統紊亂,該病癥被稱為磷酸丙糖異構酶缺乏癥。
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